Methanesulfonyl chloride → HCID 19992423, compound

HRID 345432Notes

Reaction equation

HRID 345432 reaction equation
[NH2:1][C:2]1[CH:20]=[CH:19][C:5]([O:6][CH:7]2[CH2:12][CH2:11][N:10]([C:13]3[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=3)[CH2:9][CH2:8]2)=[CH:4][CH:3]=1.[CH3:21][S:22](Cl)(=[O:24])=[O:23].C(O)C.O>N1C=CC=CC=1>[N:16]1[CH:17]=[CH:18][C:13]([N:10]2[CH2:9][CH2:8][CH:7]([O:6][C:5]3[CH:4]=[CH:3][C:2]([NH:1][S:22]([CH3:21])(=[O:24])=[O:23])=[CH:20][CH:19]=3)[CH2:12][CH2:11]2)=[CH:14][CH:15]=1

Participants

5

Reactant 3

HCID 31297Methanesulfonyl chlorideHCID 18357062HCID 18357062, compoundHCID 19096565Water ethanol

Product 1

HCID 19992423HCID 19992423, compoundYield 62.4%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Treatment of 4-(4-aminophenoxy)-1-(4-pyridyl)piperidine (see Preparation 3) (0.323 g) with methanesulphonyl chloride (0.151 g) in pyridine (10 ml) according to the method of Example 1 gave the title compound, (0.260 g), m.p. 191°-192° (from ethanol/water).

Sources & evidence

ORD record
ord-23777ef95aa14a81acba80c79f01106a
Source dataset
uspto-grants-1991_10
Patent number
US05057528

Reaction notes

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