HCID 19992431, compound → HCID 19992417, compound

HRID 345440Notes

Reaction equation

HRID 345440 reaction equation
[CH3:1][N:2]([C:15]1[CH:20]=[CH:19][N:18]=[CH:17][CH:16]=1)[CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([N+:12]([O-])=O)=[CH:8][CH:7]=1>CO>[CH3:1][N:2]([CH2:3][CH2:4][O:5][C:6]1[CH:7]=[CH:8][C:9]([NH2:12])=[CH:10][CH:11]=1)[C:15]1[CH:20]=[CH:19][N:18]=[CH:17][CH:16]=1

Participants

3

Reactant 1

HCID 19992431HCID 19992431, compound

Product 1

HCID 19992417HCID 19992417, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of the product of part (ii) (0.50 g) in methanol (30 ml) was hydrogenated at room temperature and 3.5 bar in the presence of 5% palladium on carbon (50 mg) until the required amount of hydrogen had been absorbed. The catalyst was filtered off and the filtrate was evaporated to give the product, (0.43 g), m.p. 141°-142° (from ethyl acetate/hexane).

Workup

  1. customwas hydrogenated at room temperature
  2. custom3.5 bar in the presence of 5% palladium on carbon (50 mg) until the required amount of hydrogen had been absorbed
  3. filtrationThe catalyst was filtered off
  4. customthe filtrate was evaporated
  5. customto give the product, (0.43 g), m.p. 141°-142° (from ethyl acetate/hexane)

Sources & evidence

ORD record
ord-a66493fc600d4060bb9daac4d5b87edc
Source dataset
uspto-grants-1991_10
Patent number
US05057528

Reaction notes

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