HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 6,7-Dichloro-3-methyl-4-hydroxy-4-thioureidocarbonyl-2-oxo-1,2,3,4-tetrahydroquinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Thiourea | HCID 2723790 | — |
| Reactant | 5,6-Dichloro-1-methylcarbamoylisatin | HCID 14229955 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 6,7-Dichloro-3-methyl-4-hydroxy-4-thioureidocarbonyl-2-oxo-1,2,3,4-tetrahydroquinazoline | HCID 14229996 | 33.4% |
Reaction Steps
5,6-Dichloro-1-methylcarbamoylisatin (9.6 g) is suspended in tetrahydrofuran (100 ml) and thereto are added thiourea (3.0 g) and triethylamine (5.6 ml), and the mixture is stirred at room temperature for 5 hours. The resulting precipitates are taken by filtration to give 6,7-dichloro-3-methyl-4-hydroxy-4-thioureidocarbonyl-2-oxo-1,2,3,4-tetrahydroquinazoline (4.1 g). M.p. 225-228° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04762839 |
| Source dataset | uspto-grants-1988_08 |
| ORD ID | ord-bcc70a3b9eb942c1b7c9a6cc28b10ae7 |
| Source note | uspto-grants-1988_08 |