Potassium Hydroxide → HCID 14698744, compound

Participants

Reaction Steps

A mixture of 16.3 g (0.05 mole) of 1-acetyl-α-(4-fluorophenyl)-α-phenyl-4-piperidinemethanol and 5.6 g (0.1 mole) of potassium hydroxide in 150 ml of 95% ethanol and 20 ml of water was heated at reflux for 18 h. The mixture was poured into 1.5 L of ice-water and a solid precipitated. The solid was collected by filtration and dried. The gummy solid was dissolved in ethyl ether, filtered, and the filtrate slowly evaporated to 50 ml. The resulting solid was collected by filtration and recrystallized from 2-propanol/isopropyl ether to yield 3.5 g (25%) of white solid, mp 144.5°-146° C.

Provenance & Evidence