HCID 15020351, compound → HCID 15020352, compound

Participants

Reaction Steps

A solution of 39.3 g (0.1 mol) of the base of α,α-bis(3-fluorophenyl)-1-(phenylmethyl)-4-piperidinemethanol in 750 ml of absolute ethanol was hydrogenated over 1 tsp of 5% Pd/C in a Parr apparatus at 50 psi and 60° C. for 3.5 days. The mixture was cooled and filtered through Celite®. The filtrate was concentrated, and the residue was dissolved in ethyl ether and filtered through cotton to remove some insoluble material. The filtrate was concentrated to give a gum which crystallized when triturated with petroleum ether (30°-60° C.). The solid was collected by filtration and dried to yield 27.9 g (92%) of white solid. An analytical sample, mp 117°-118° C., was recrystallized from isopropyl ether/2-propanol.

Provenance & Evidence