反应详情

A mixture of 35.8 g (0.1 mole) of α,α-diphenyl-1-(phenylmethyl)-4-piperidinemethanol and 1 tsp of 5% Pd/C in 500 ml of absolute ethanol was hydrogenated at 60° C. in a Parr apparatus for 3 days. The mixture was filtered through Celite® and the filtrate was concentrated to give a solid residue. The solid was triturated with petroleum ether (30°-60° C.), collected by filtration and dried to give 26.7 g (quantitative) of white solid. An analytical sample, mp 160°-161° C., was prepared from 2-propanol-isopropyl ether.

1. filtrationThe mixture was filtered through Celite®
2. concentrationthe filtrate was concentrated
3. customto give a solid residue
4. customThe solid was triturated with petroleum ether (30°-60° C.)
5. filtrationcollected by filtration
6. customdried
7. customto give 26.7 g (quantitative) of white solid