反应详情

3-Methyl-4-hydroxy-4-ureidocarbonyl-2-oxo-1,2,3,4-tetrahydroquinazoline (1.5 g) is added to 1,2-dichlorobenzene (30 ml), and the mixture is refluxed with stirring for 1.5 hour. After cooling, the precipitates are taken by filtration and recrystallized from dimethylsulfoxide to give 3-methyl-spiro[1,2,3,4-tetrahydroquinazoline-4,4'-imidazolidine]-2,2',5'-trione (0.8 g).

1. temperaturethe mixture is refluxed
2. temperatureAfter cooling
3. filtrationthe precipitates are taken by filtration
4. customrecrystallized from dimethylsulfoxide