反应详情

A solution of 5.66 g (0.0179 mole) of 4-[bis(3,4-difluorophenyl)methyl]pyridine and 12 drops of 50% NaOH in 50 ml of DMSO was stirred at room temperature for 4.5 h with air bubbling through the reaction mixture. Water was added to the solution, and a tan precipitate was collected. This was recrystallized from CH2Cl2 -hexane to give 4.75 g (79.9%) of the title compound as a white, crystalline solid, mp 147°-149° C.

1. custombubbling through the reaction mixture
2. additionWater was added to the solution
3. customa tan precipitate was collected
4. customThis was recrystallized from CH2Cl2 -hexane