Water → 4-[Bis(4-fluorophenyl)hydroxymethyl]-1-piperidinepropanamide

Participants

Reaction Steps

A mixture of 15.2 g (0.05 mole) of α,α-bis(4-fluorophenyl)-4-piperidinemethanol, 5.9 g (0.055 mole) of 3-chloropropionamide (Aldrich), 15.9 g (0.15 mole) of anhydrous sodium bicarbonate and 0.4 g of potassium iodide in 150 ml of dimethylformamide was heated on a steam bath for 24 h. The mixture was poured into 1.5 L of water and a solid precipitated. After standing overnight, the solid was collected by filtration, washed with water, dried, and recrystallized from benzene to yield 13.9 g (74%) of white solid, mp 136°-137° C.

Provenance & Evidence