Water → HCID 19992265, compound

Participants

Reaction Steps

A mixture of 12.0 g (0.040 mole) of α,α-bis(4-fluorophenyl)-4-piperidine methanol, 10.3 g (0.040 mole) of 3-chloro-N,N-diphenylpropanamide, 17.0 g (0.160 mole) of anhydrous sodium carbonate and 0.3 g (0.002 mole) of potassium iodide in 100 ml of N,N-dimethylformamide was heated on a steam bath for 16 h. The mixture was poured into 2 L of water and a solid precipitated. After standing 3 h, the solid was collected by filtration, washed with water, dried and recrystallized from benzene-petroleum ether (30°-60° C.) to yield 18.7 g (90%) of a white solid, mp 160°-162° C.

Provenance & Evidence