Hydrochloric Acid → HCID 67913269, compound

Participants

Reaction Steps

A solution of 5.6 g (0.015 mole) of 5-(4-chlorophenyl)-3-dimethylamino-1H-pyrazole-4-acetic acid butyl ester monohydrochloride in 150 ml of 200 ethanol was treated with 1 ml of concentrated hydrochloric acid and heated at reflux for 24 hours. The reaction mixture was concentrated in vacuo to a solid residue, 5.5 g. Recrystallization from 2-propanol yielded 3.1 g (60%) of white crystalline product, mp 211°-215° C. with degassing.

Provenance & Evidence