Ammonia → HCID 10199053, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4.5 g (0.015 mole) of 3-(dimethylamino)-5-(4-methylphenyl)pyrazole-4-acetic acid monohydrochloride and 4 ml (0.03 mole) of triethylamine in 75 ml of methylene chloride was stirred under nitrogen until all the solids dissolved, then cooled to -30° C. in a dry ice/acetone batch and treated with 1.7 g (0.0152 mole) of ethyl chloroformate added dropwise through a septum with a syringe and needle. The reaction mixture was cooled to 0° C. with an ice-brine bath and ammonia (5 ml in 10 ml of methylene chloride) was added. The reaction was stirred for 16 hours as it warmed to ambient temperature.

Provenance & Evidence