HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 5-Fluoro-1-methylcarbamoylisatin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methyl Isocyanate | HCID 12228 | — |
| Reactant | 5-Fluoroisatin | HCID 236566 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5-Fluoro-1-methylcarbamoylisatin | HCID 14229948 | 74.5% |
Reaction Steps
A mixture of 5-fluoroisatin (9.9 g), triethylamine (1 ml) and dimethylformamide (30 ml) is stirred under ice-cooling, and thereto is added dropwise methyl isocyanate (3 g) at the same temperature. The mixture is stirred at room temperature for 30 minutes, and the precipitates are taken by filtration to give 5-fluoro-1-methylcarbamoylisatin (8.7 g). M.p. 230°-232° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04762839 |
| Source dataset | uspto-grants-1988_08 |
| ORD ID | ord-c25576f7a14c4b82ae9916dfb75fb8cd |
| Source note | uspto-grants-1988_08 |