反应详情

A mixture of 38.1 parts of 3,4,4-trimethoxy-1-(phenylmethyl)piperidine and 1200 parts of sulfuric acid solution 1% was stirred and refluxed for 7 hours. The reaction mixture was allowed to cool overnight to room temperature and treated with sodium carbonate till a turbid solution was obtained. The product was extracted with 1,1'-oxybisethane. The extract was washed with water, dried, filtered and evaporated, yielding 28.8 parts (98.6%) of 3-methoxy-1-(phenylmethyl)-4-piperidinone as an oily residue (intermediate 60).

1. temperaturerefluxed for 7 hours
2. temperatureto cool overnight to room temperature
3. customwas obtained
4. extractionThe product was extracted with 1,1'-oxybisethane
5. washThe extract was washed with water
6. customdried
7. filtrationfiltered
8. customevaporated