Ammonia → 1-Benzyl-4-piperidylamine

HRID 345556Notes

Reaction equation

HRID 345556 reaction equation
CO[CH:3]1[C:8](=O)[CH2:7][CH2:6][N:5]([CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH2:4]1.[NH3:17].[H][H]>[Ni].CO>[C:11]1([CH2:10][N:5]2[CH2:6][CH2:7][CH:8]([NH2:17])[CH2:3][CH2:4]2)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Participants

6

Reactant 3

HCID 222AmmoniaHCID 15078438HCID 15078438, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 4158521-Benzyl-4-piperidylamine

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

A mixture of 83 parts of 3-methoxy-1-(phenylmethyl)-4-piperidinone, oxime and 400 parts of methanol saturated with ammonia was hydrogenated at normal pressure and at 50° C. with 6 parts of Raney-nickel catalyst. After the calculated amount of hydrogen was taken up, the catalyst was filtered off and the filtrate was evaporated, yielding 78 parts (100%) of (cis+trans)-3-methoxy-1-(phenylmethyl-4-piperidinamine as a residue (intermediate 71).

Workup

  1. filtrationthe catalyst was filtered off
  2. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-0030dbe03a6543c29be834494d2b2d53
Source dataset
uspto-grants-1991_10
Patent number
US05057525

Reaction notes

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