反应详情

To a stirred mixture of 46.46 parts of 1,4-cyclohexanediol and 135 parts of N,N-dimethylformamide were added 5.28 parts of sodium hydride dispersion 50% at a temperature below 20° C. Stirring was continued for 2 hours at room temperature under nitrogen atmosphere. Then there were added dropwise 15.9 parts of 1,4-difluoro-2-nitrobenzene at about 20° C. Upon completion, stirring was continued overnight at room temperature. The reaction mixture was poured onto water. The precipitated product was filtered off and taken up in trichloromethane. The solution was washed with water, dried, filtered and evaporated. The residue was boiled in 2-propanol. Upon cooling, the precipitate was filtered off and the filtrate was evaporated. The residue was purified by column-chromatography over silica gel using a mixture of trichloromethane and methanol (95:5 by volume) as eluent. The pure fractions were collected and the eluent was evaporated. The residue was stirred in petroleumether. The product was filtered off and dried, yielding 17.1 parts of 4-(4-fluoro-2-nitrophenoxy)cyclohexanol; mp. 150.8° C. (intermediate 85).

1. stirringUpon completion, stirring
2. waitwas continued overnight at room temperature
3. additionThe reaction mixture was poured onto water
4. filtrationThe precipitated product was filtered off
5. washThe solution was washed with water
6. customdried
7. filtrationfiltered
8. customevaporated
9. temperatureUpon cooling
10. filtrationthe precipitate was filtered off
11. customthe filtrate was evaporated
12. customThe residue was purified by column-chromatography over silica gel using
13. additiona mixture of trichloromethane and methanol (95:5 by volume) as eluent
14. customThe pure fractions were collected
15. customthe eluent was evaporated
16. stirringThe residue was stirred in petroleumether
17. filtrationThe product was filtered off
18. customdried