HCID 19883511, compound → HCID 19883537, compound

HRID 345578Notes

Reaction equation

HRID 345578 reaction equation
[CH2:1]([N:3]([CH2:24][CH3:25])[CH2:4][CH2:5][O:6][CH:7]1[C:12]([O:15][CH3:16])([O:13][CH3:14])[CH2:11][CH2:10][N:9](CC2C=CC=CC=2)[CH2:8]1)[CH3:2].[H][H]>[Pd].CO>[CH2:24]([N:3]([CH2:1][CH3:2])[CH2:4][CH2:5][O:6][CH:7]1[C:12]([O:15][CH3:16])([O:13][CH3:14])[CH2:11][CH2:10][NH:9][CH2:8]1)[CH3:25]

Participants

5

Reactant 2

HCID 19883511HCID 19883511, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 19883537HCID 19883537, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of 13.5 parts of N,N-diethyl-2-[[4,4-dimethoxy-1-(phenylmethyl)-3-piperidinyl]oxy]ethanamine and 120 parts of methanol was hydrogenated at normal pressure and at room temperature with 2 parts of palladium-on-charcoal catalyst 10%. After the calculated amount of hydrogen was taken up, the catalyst was filtered off and the filtrate was evaporated, yielding 10.5 parts (100%) of N,N-diethyl-2-[(4,4-dimethoxy-3-piperidinyl)oxy]ethanamine as a residue (intermediate 109).

Workup

  1. filtrationthe catalyst was filtered off
  2. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-6f3c3304f543489cbac4d2708102ae82
Source dataset
uspto-grants-1991_10
Patent number
US05057525

Reaction notes

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