HCID 15096800, compound → HCID 67914534, compound

Participants

Reaction Steps

A mixture of 150 parts of cis-N-[3-(phenylmethoxy)-1-(phenylmethyl)-4-piperidinyl]benzamide and 400 parts of methanol was hydrogenated at normal pressure and at room temperature with 9 parts of palladium-on-charcoal catalyst 10%. After the calculated amount of hydrogen was taken up, the catalyst was filtered off and the filtrate was evaportated. The residue was crystallized from acetonitrile. The product was filtered off and dried, yielding a firs fraction of 42 parts of cis-N-[3-(phenylmethoxy)-4-piperidinyl]-benzamide. The mother-liquor was evaporated, yielding 70 parts of cis-N-[3-(phenylmethoxy)-4-piperidinyl]benzamide as an oily residue (compound 221).

Provenance & Evidence