HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 345637Generated: October 31, 2026
1-Acetyl-4-(2,5-difluorobenzoyl)-4-hydroxypiperidine → 4-(2,5-Difluorobenzoyl)-4-hydroxypiperidine
https://huagongshe.com/reaction/345637
Participants
| Role | Name | HCID | Charge |
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| Reactant | 1-Acetyl-4-(2,5-difluorobenzoyl)-4-hydroxypiperidine | HCID 13800134 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | 4-(2,5-Difluorobenzoyl)-4-hydroxypiperidine | HCID 13800135 | 91.3% |
Reaction Steps
A suspension of 5.66 g of 1-acetyl-4-(2,5-difluorobenzoyl)-4-hydroxypiperidine in 10 ml of 6N hydrochloric acid was stirred at reflux, under nitrogen for 3.5 hrs. The reaction mixture was allowed to cool to 0° C. whereupon a solid separated. The solid was collected, washed with ice-cold acetone and dried to give 4.4 g (80%) of product, mp 191°-193° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05057611 |
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| Source dataset | uspto-grants-1991_10 |
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| ORD ID | ord-d32f1d4c15a54b209a5a8535f744dcaf |
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| Source note | uspto-grants-1991_10 |
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