HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 345691Generated: October 30, 2026
Trimethylamine → Trimethyl [3-[3-[3-(1-methyl-3-indolyl)-2,5-dioxo-3-pyrrolin-4-yl]-1-indolyl]propyl]ammonium methylsulphonate
https://huagongshe.com/reaction/345691
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trimethylamine | HCID 1146 | — |
| Reactant | 3-(1-methyl-3-indolyl)-4-[1-[3-(methylsulphonyloxy)propyl]-3-indolyl]-1H-pyrrole-2,5-dione | HCID 15163051 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Trimethyl [3-[3-[3-(1-methyl-3-indolyl)-2,5-dioxo-3-pyrrolin-4-yl]-1-indolyl]propyl]ammonium methylsulphonate | HCID 86745175 | — |
Reaction Steps
A mixture of 173 mg of the product of Example 58 and 2 ml of a 33% solution of trimethylamine in ethanol was heated at 90° C. for 3 hours. The solvent was evaporated and the residue was purified on silica gel with dichloromethane/methanol/acetic acid/water (60:18:2:3). Trituration with ethyl acetate gave 75 mg of trimethyl [3-[3-[3-(1-methyl-3-indolyl)-2,5-dioxo-3-pyrrolin-4-yl]-1-indolyl]propyl]ammonium methylsulphonate, m.p. 180°-185° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05057614 |
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| Source dataset | uspto-grants-1991_10 |
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| ORD ID | ord-9ffd713f37984fb797011a4e8f7b9ce9 |
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| Source note | uspto-grants-1991_10 |
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