HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 3-[1-(2-hydroxyethyl)-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)-2,5-dihydro-1H-pyrrole-2,5-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 3-[1-(2-Acetoxyethyl)-3-indolyl]-4-(1-methyl-3-indolyl)furan-2,5-dione | HCID 15163046 | — |
| Solvent | Ammonia | HCID 222 | — |
| Product | 3-[1-(2-hydroxyethyl)-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)-2,5-dihydro-1H-pyrrole-2,5-dione | HCID 5327928 | — |
Reaction Steps
A solution of 1.6 g of 3-[1-(2-acetoxyethyl)-3-indolyl]-4-(1-methyl-3-indolyl)furan-2,5-dione in 4 ml of DMF and 8 ml of 33% aqueous ammonia was heated to 160° C. for 4 hours. The precipitate was filtered off and dried to give 1.04 g of 3-[1-(2-hydroxyethyl)-3-indolyl]-4-(1-methyl-3-indolyl)-1H-pyrrole-2,5-dione, m.p. 250°-252° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05057614 |
| Source dataset | uspto-grants-1991_10 |
| ORD ID | ord-5a3d081170634c44a6f14ec1ebc57770 |
| Source note | uspto-grants-1991_10 |