Dimethyl Sulfoxide → HCID 18780292, compound

HRID 345704Notes

Reaction equation

HRID 345704 reaction equation
[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:11]2[C:12](=[O:34])[NH:13][C:14](=[O:33])[C:15]=2[C:16]2[C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[N:18]([CH2:25][CH2:26]COS(C)(=O)=O)[CH:17]=2)=[CH:3]1.C[S-].[Na+].[CH3:38][S:39]([CH3:41])=O>O>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([C:11]2[C:12](=[O:34])[NH:13][C:14](=[O:33])[C:15]=2[C:16]2[C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[N:18]([CH2:25][CH2:26][CH2:38][S:39][CH3:41])[CH:17]=2)=[CH:3]1

Participants

5

Reactant 3

HCID 679Dimethyl SulfoxideHCID 4378561Sodium methanethiolateHCID 151630513-(1-methyl-3-indolyl)-4-[1-[3-(methylsulphonyloxy)propyl]-3-indolyl]-1H-pyrrole-2,5-dione

Product 1

HCID 18780292HCID 18780292, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

100 mg of the product of Example 58 in 5 ml of DMSO were treated with 30 mg of sodium methanethiolate. The solution was stirred for 30 minutes and then diluted with water. The precipitate was filtered off, washed with water and dried to give 52 mg of 3-(1-methyl-3-indolyl)-4-[1-[3-(methylthio)propyl]-3-indolyl]-1H-pyrrole-2,5-dione, m.p. 222°-224° C.

Workup

  1. filtrationThe precipitate was filtered off
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-9d84450b09ae450897a79350dc01d6aa
Source dataset
uspto-grants-1991_10
Patent number
US05057614

Reaction notes

Loading…