HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethyl Sulfoxide → HCID 18780220, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethyl Sulfoxide | HCID 679 | — |
| Reactant | 3-(1-methyl-3-indolyl)-4-[1-[3-(methylsulphonyloxy)propyl]-3-indolyl]-1H-pyrrole-2,5-dione | HCID 15163051 | — |
| Reactant | Potassium 2-thienylacetate | HCID 23696799 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 18780220 | HCID 18780220 | — |
Reaction Steps
838 mg of the product of Example 58 in 15 ml of DMSO were treated with 600 mg of potassium thiolacetate. The solution was stirred for 3 hours and then diluted with water. The solution was extracted with ethyl acetate and the ethyl acetate extracts were dried. Concentration and chromatography on silica gel with ethyl acetate gave 723 mg of 3-[1-[3-(acetylthio)propyl]-3-indolyl]-4-(1-methyl-3-indolyl)-1H-pyrrole-2,5-dione, m.p. 210°-213° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05057614 |
| Source dataset | uspto-grants-1991_10 |
| ORD ID | ord-6c421a4e2149406ebcb5b165958dda3b |
| Source note | uspto-grants-1991_10 |