Water → (S)-4-(1-oxo-2-methylbutyl)phenyl 4-(5-octyl-2-pyrimidinyl)benzoate

HRID 345742Notes

Reaction equation

HRID 345742 reaction equation
[CH2:1]([C:9]1[CH:10]=[N:11][C:12]([C:15]2[CH:23]=[CH:22][C:18]([C:19](Cl)=[O:20])=[CH:17][CH:16]=2)=[N:13][CH:14]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].N1C=CC=CC=1.[O:30]=[C:31]([C:36]1[CH:41]=[CH:40][C:39]([OH:42])=[CH:38][CH:37]=1)[C@@H:32]([CH3:35])[CH2:33][CH3:34].O>C(Cl)(Cl)(Cl)Cl.CCCCCC.C(OCC)(=O)C.C(OCC)C>[CH2:1]([C:9]1[CH:10]=[N:11][C:12]([C:15]2[CH:23]=[CH:22][C:18]([C:19]([O:42][C:39]3[CH:38]=[CH:37][C:36]([C:31](=[O:30])[C@@H:32]([CH3:35])[CH2:33][CH3:34])=[CH:41][CH:40]=3)=[O:20])=[CH:17][CH:16]=2)=[N:13][CH:14]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]

Participants

8

Reactant 4

HCID 962WaterHCID 1049PyridineHCID 197340404-(5-Octyl-2-pyrimidinyl)benzoic acid chlorideHCID 53647809(S)-4-(1-oxo-2-methylbutyl)phenol

Product 1

HCID 53902374(S)-4-(1-oxo-2-methylbutyl)phenyl 4-(5-octyl-2-pyrimidinyl)benzoate

Reagents, catalysts & solvents 3

HCID 3283Diethyl EtherSolventHCID 5943Carbon TetrachlorideSolvent2×HCID 21226206Ethyl acetate hexaneSolvent

Procedure

10 ml of CCl4, 5 ml of thionyl chloride and one drop of dimethylformamide were added to 2.0 g of 4-(5-octyl-2-pyrimidinyl)benzoic acid. The mixture was refluxed for 3 hours under stirring. The solvent was distilled off initially under normal pressure and then under reduced pressure. As a result, 2.2 g of 4-(5-octyl-2-pyrimidinyl)benzoic acid chloride was obtained in the form of a colorless plate-form crystal. 1.2 g of the thus obtained 4-(5-octyl-2-pyrimidinyl)benzoic acid chloride was dissolved in a mixed solvent composed of 20 ml of CCl4 and 5 ml of anhydrous pyridine under stirring. The thus obtained solution was added with a solution prepared by dissolving 0.7 g of (S)-4-(1-oxo-2-methylbutyl)phenol in 10 ml of CCl4, and the admixture was stirred at the room temperature for one night. The admixture was heated to reflux for 3 hours. 200 ml of water and 100 ml of ethyl ether were added to the reaction admixture, followed by stirring. The organic phase was separated, and rinsed initially with a dilute hydrochloric acid solution, then with an aqueous solution of NaHCO3 and finally with a saturated aqueous solution of NaCl. The rinsed organic phase was added with anhydrous Na2SO4 and allowed to stand for one night to dry the same. After removing the drying agent by filtration, the solvent was distilled off to obtain 1.86 g of a crude product. The crude product was refined through silica gel column chromatography while using a mixed solvent of hexane/ethyl acetate (ratio by volume: 8/2). The refined product was recrystallized from ethanol to obtain 200 mg of (S)-4-(1-oxo-2-methylbutyl)phenyl 4-(5-octyl-2-pyrimidinyl)benzoate in the form of a colorless crystal.

Workup

  1. additionThe thus obtained solution was added with a solution
  2. customprepared
  3. stirringthe admixture was stirred at the room temperature for one night
  4. temperatureThe admixture was heated
  5. temperatureto reflux for 3 hours
  6. stirringby stirring
  7. customThe organic phase was separated
  8. washrinsed initially with a dilute hydrochloric acid solution
  9. additionThe rinsed organic phase was added with anhydrous Na2SO4
  10. waitto stand for one night
  11. customto dry the same
  12. customAfter removing the drying agent
  13. filtrationby filtration
  14. distillationthe solvent was distilled off
  15. customto obtain 1.86 g of a crude product
  16. customThe refined product was recrystallized from ethanol

Sources & evidence

ORD record
ord-56363eaf291048ca8697a33022ea7e6e
Source dataset
uspto-grants-1991_10
Patent number
US05059345

Reaction notes

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