2,3-Dimethyl-2-butene → 1-Azetidinesulfonyl chloride, 2,2,3,3-tetramethyl-4-oxo-

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Reaction Steps

To a stirred solution of 0.06 mol CSI (chlorosulfonyl isocyanate) in dry ether under nitrogen, 0.06 mol of 2,3-dimethyl-but-2-ene was added dropwise at a temperature of 30° to 35° C. The reaction mixture was stirred for a further 1 hour while it was cooled to room temperature. The solution was then cooled in a salt-ice bath and the product which crystallized out as white solid was filtered off and carried through to the next step.

Provenance & Evidence