HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Nitrate → 2-Chloro-5-fluoro-4-methyl-3-nitro-benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Nitrate | HCID 24434 | — |
| Reactant | 2-Chloro-5-fluoro-4-methylbenzoic acid | HCID 13657438 | — |
| Solvent | Sulfuric Acid | HCID 1118 | — |
| Product | 2-Chloro-5-fluoro-4-methyl-3-nitro-benzoic acid | HCID 13657439 | — |
Reaction Steps
20 g of 2-chloro-5-fluoro-4-methylbenzoic acid are initially introduced into 60 ml of concentrated H2SO4. 12.3 g of KNO3 are added in portions, while cooling with ice. The mixture is then warmed to 50° for 2 hours and subsequently poured onto ice. After isolation and recrystallization from toluene, 18.8 g of 2-chloro-5-fluoro-4-methyl-3-nitrobenzoic acid of melting point 186°-88° are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04762844 |
| Source dataset | uspto-grants-1988_08 |
| ORD ID | ord-b82bbfc1e2be46f795a1618486ae0bdb |
| Source note | uspto-grants-1988_08 |