HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Methyl 3-amino-2-chloro-5-fluoro-4-methylbenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 3-Amino-2-chloro-5-fluoro-4-methylbenzoic acid | HCID 13657440 | — |
| Solvent | Water | HCID 962 | — |
| Product | Methyl 3-amino-2-chloro-5-fluoro-4-methylbenzoate | HCID 13657452 | — |
Reaction Steps
12 g of 3-amino-2-chloro-5-fluoro-4-methylbenzoic acid are initially introduced into 60 ml of MeOH. HCl gas is passed in for 20 minutes and is then boiled under reflux for 5 hours. Thereafter, the mixture is poured into water and rendered alkaline with sodium carbonate and the product is isolated. Yield: 8 g, melting point: 51°-52°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04762844 |
| Source dataset | uspto-grants-1988_08 |
| ORD ID | ord-be8a1afed337406c888ecd39e8cf4276 |
| Source note | uspto-grants-1988_08 |