6-Benzyl-octahydropyrrolo[3,4-b][1,4]oxazine → Octahydropyrrolo[3,4-b][1,4]oxazine

HRID 345790Notes

Reaction equation

HRID 345790 reaction equation
C([N:8]1[CH2:16][CH:15]2[CH:10]([NH:11][CH2:12][CH2:13][O:14]2)[CH2:9]1)C1C=CC=CC=1>CO.[Pd]>[CH:15]12[CH2:16][NH:8][CH2:9][CH:10]1[NH:11][CH2:12][CH2:13][O:14]2

Participants

4

Reactant 1

HCID 150699806-Benzyl-octahydropyrrolo[3,4-b][1,4]oxazine

Product 1

HCID 15069981Octahydropyrrolo[3,4-b][1,4]oxazine

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

7.2 g (33 mmol) of 8-benzyl-2-oxa-5,8-diazabicyclo[4.3.0]nonane are hydrogenated in 400 ml of methanol with 2.5 g of palladium-on-active charcoal (10% of Pd) under 50 bar at 100° C. The catalyst is filtered off with suction, the filtrate is concentrated and the residue is distilled.

Workup

  1. filtrationThe catalyst is filtered off with suction
  2. concentrationthe filtrate is concentrated
  3. distillationthe residue is distilled

Sources & evidence

ORD record
ord-3961f500db6f4ab7b1d60f68f0c5e15b
Source dataset
uspto-grants-1991_10
Patent number
US05059597

Reaction notes

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