HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 1-Benzyl-3-(2-chloroethylamino)pyrrolidine-2,5-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Benzylmaleimide | HCID 74204 | — |
| Reactant | 2-Chloroethylamine hydrochloride | HCID 9793737 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 1-Benzyl-3-(2-chloroethylamino)pyrrolidine-2,5-dione | HCID 15070002 | — |
Reaction Steps
74.8 g (0.4 mol) of N-benzylmaleimide are reacted with 58 g (0.5 mol) of 2-chloroethylamine hydrochloride and 50.5 g (0.5 mol) of triethylamine in accordance with the working instructions of Example Ia. After working up by chromatography, 81.6 g (77% of theory) of an oil with an RF value of 0.24 (on silica gel using ethyl acetate:petroleum ether=1:1) are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05059597 |
| Source dataset | uspto-grants-1991_10 |
| ORD ID | ord-693c3e101c4740969cfe48357afaed28 |
| Source note | uspto-grants-1991_10 |