HCID 15069996, compound → Ethyl 3-(hydroxymethyl)-4-(methylamino)pyrrolidine-1-carboxylate

HRID 345821Notes

Reaction equation

HRID 345821 reaction equation
[CH3:1][N:2]1[O:9][CH2:8][CH:7]2[CH:3]1[CH2:4][N:5]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH2:6]2>C(O)C.[Pd]>[OH:9][CH2:8][CH:7]1[CH2:6][N:5]([C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH2:4][CH:3]1[NH:2][CH3:1]

Participants

4

Reactant 1

HCID 15069996HCID 15069996, compound

Product 1

HCID 15070021Ethyl 3-(hydroxymethyl)-4-(methylamino)pyrrolidine-1-carboxylate

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

10 g (50 mmol) of ethyl 2-methyl-3-oxa-2,7-diazabicyclo[3.3.0]octane-7-carboxylate (Example H d)) are hydrogenated in 200 ml of ethanol on 3 g of Pd-on-active charcoal (10% of Pd) at 50° C. under 50 bar. The catalyst is filtered off, the filtrate is concentrated and the residue is distilled.

Workup

  1. filtrationThe catalyst is filtered off
  2. concentrationthe filtrate is concentrated
  3. distillationthe residue is distilled

Sources & evidence

ORD record
ord-7369bfbdb18043f7b472387364a8e838
Source dataset
uspto-grants-1991_10
Patent number
US05059597

Reaction notes

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