HCID 15070022, compound → 2-Methyl-4-oxa-2,8-diazabicyclo[4.3.0]nonane

HRID 345822Notes

Reaction equation

HRID 345822 reaction equation
[CH3:1][N:2]1[CH2:10][O:9][CH2:8][CH:7]2[CH:3]1[CH2:4][N:5](C(OCC)=O)[CH2:6]2>O>[CH3:1][N:2]1[CH2:10][O:9][CH2:8][CH:7]2[CH:3]1[CH2:4][NH:5][CH2:6]2

Participants

3

Reactant 1

HCID 15070022HCID 15070022, compound

Product 1

HCID 150700232-Methyl-4-oxa-2,8-diazabicyclo[4.3.0]nonane

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

9 g (42 mmol) of ethyl 2-methyl-4-oxa-2,8-diazabicyclo[4.3.0]nonane-8-carboxylate are heated under reflux with 28 g of Ba(OH)2.8H2O in 280 ml of water overnight. The BaCO3 is filtered off with suction, the filtrate is concentrated and the residue is boiled up with dioxane. The dioxane solution is concentrated and the residue is distilled.

Workup

  1. filtrationThe BaCO3 is filtered off with suction
  2. concentrationthe filtrate is concentrated
  3. concentrationThe dioxane solution is concentrated
  4. distillationthe residue is distilled

Sources & evidence

ORD record
ord-6f6007457c2e4818a86c1d4859628d37
Source dataset
uspto-grants-1991_10
Patent number
US05059597

Reaction notes

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