反应详情

A mixture of 1-phenyl-3,4-dihydroisoquinoline (1.0 g) and benzyliodide (1.26 g) in acetonitrile (7 ml) was refluxed for 1 hour. After allowing to cool to room temperature, the reaction mixture was evaporated in vacuo and the residual precipitate was recrystallized from a mixture of diethyl ether (5 ml) and acetonitrile (3 ml). The crystal was collected by filtration, washed with diethyl ether and dried in vacuo to give 1-phenyl-2-benzyl-3,4-dihydroisoquinolinium iodide (1.52 g).

1. temperaturewas refluxed for 1 hour
2. customthe reaction mixture was evaporated in vacuo
3. customthe residual precipitate was recrystallized from a mixture of diethyl ether (5 ml) and acetonitrile (3 ml)
4. filtrationThe crystal was collected by filtration
5. washwashed with diethyl ether
6. customdried in vacuo