Imidazole → HCID 14798983, compound

Participants

Reaction Steps

4 g (59 mmol) of imidazole and 2.1 g (10 mmol) of 2-(1-cyanocyclopropyl)-2-(4-fluorophenyl)oxirane (IV-2, Example 33) in 20 ml of abs. acetonitrile are heated under reflux for 8 h under a nitrogen atmosphere. After evaporation of the solvent in vacuo, the residue is taken up in ethyl acetate. The mixture is washed with water and dried over Na2SO4, and the solvent is evaporated in vacuo. Chromatographic purification on silica gel (eluent: dichloromethane containing 2% ethanol) gives 1.1 g (39% of theory) of 1-(1-cyanocyclopropyl)-1-(4-fluorophenyl)-2 -(imidazol-1-yl)ethanol having a melting point of 173° C. (dec.), 1H--NMR (CDCl3):

Provenance & Evidence