Dimethyl Sulfoxide → HCID 14798966, compound

Participants

Reaction Conditions

Reaction Steps

10 ml of abs. DMSO are added dropwise at 10° C. to 2 g (10 mmol) of trimethylsulphonium iodide and 0.2 g (7 mmol) of sodium hydride (80% in oil). The mixture is stirred for 1 h at 20° C. After this, a solution of 1 g (5 mmol) of 1-cyanocyclopropyl 2-phenylethyl-ketone (compound II-16, Example 32) in 5 ml of abs. DMSO is added dropwise and the mixture is allowed to react for 4 h at 20° C. The solution is poured into water and extracted using ethyl acetate, the organic phase is dried with Na2SO4 and the solvent is evaporated in vacuo. 0.8 g (75% of theory) is obtained in the form of a colorless oil,

Provenance & Evidence