Acetic Acid → HCID 14405001, compound

HRID 345869Notes

Reaction equation

HRID 345869 reaction equation
[Cl:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([F:9])=[C:4]([Cl:10])[C:3]=1[OH:11].C(O)(=O)C.[N+:16]([O-])([OH:18])=[O:17]>ClCCl>[Cl:1][C:2]1[C:7]([F:8])=[C:6]([N+:16]([O-:18])=[O:17])[C:5]([F:9])=[C:4]([Cl:10])[C:3]=1[OH:11]

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 944Nitric AcidHCID 27825072,6-dichloro-3,5-difluorophenol

Product 1

HCID 14405001HCID 14405001, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

20 g of 2,6-dichloro-3,5-difluorophenol are initially introduced into 70 ml of acetic acid, and 8 g of 98% strength nitric acid are added dropwise. Subsequently, the mixture is then stirred for 2 hours at room temperature, taken up in 150 ml of dichloromethane and washed twice with water. 18 g of product remain after distilling off the dichloromethane. 94% pure in accordance with GC analysis.

Workup

  1. additionare added dropwise
  2. washwashed twice with water
  3. distillationafter distilling off the dichloromethane

Sources & evidence

ORD record
ord-38eeb9562c7345a98cc33b754b192c11
Source dataset
uspto-grants-1991_10
Patent number
US05059623

Reaction notes

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