HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluoro-4-methyl-5-nitrobenzoic acid → 3-Amino-5-fluoro-4-methylbenzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluoro-4-methyl-5-nitrobenzoic acid | HCID 21298245 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 3-Amino-5-fluoro-4-methylbenzoic acid | HCID 21298250 | 91.2% |
Reaction Steps
520 g of 3-fluoro-4-methyl-5-nitro-benzoic acid are hydrogenated in 3,500 ml of dioxane with 50 g of Pd-C catalyst (5% strength) at 50° C. and under 30 bar. The catalyst is then filtered off with suction and the solution is concentrated. 403 g of 3-fluoro-4-methyl-5-amino-benzoic acid are obtained as crude material.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04762844 |
| Source dataset | uspto-grants-1988_08 |
| ORD ID | ord-1184242b8cd44410a0e50e44896bc021 |
| Source note | uspto-grants-1988_08 |