反应详情

A solution of 3-(2,4,5-trifluorophenyl)prop-2-yn-1-ol (90 mg, 0.48 mmol) in diethyl ether (10 ml) was hydrogenated over 10% palladium on carbon at room temperature for 15 hours. The mixture was filtered through celite and the filtrate on evaporation gave an oil, which was flash chromatographed on silica using 10% ethyl ether/hexane. Fractions with Rf of about 0.16 on evaporation gave the title alcohol as a colorless oil.

1. filtrationThe mixture was filtered through celite
2. customthe filtrate on evaporation
3. customgave an oil, which
4. customchromatographed on silica using 10% ethyl ether/hexane
5. customFractions with Rf of about 0.16 on evaporation