HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 345924Generated: October 31, 2026
Sodium Hydroxide → 3-(3-(2-Quinolinylmethyloxy)phenoxymethyl)benzoic acid
https://huagongshe.com/reaction/345924
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Methyl 3-(3-(2-quinolinylmethyloxy)phenoxymethyl)benzoate | HCID 10111528 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-(3-(2-Quinolinylmethyloxy)phenoxymethyl)benzoic acid | HCID 9952064 | — |
Reaction Steps
A mixture of 1.6 g of methyl 3-(3-(2-quinolinylmethyloxy)phenoxymethyl)benzoate and 0.5 g of NaOH in 20 ml of THF and 5 ml of H2O is heated at 50° C. overnight. The reaction mixture is acidified to pH 4 in 1N HCl solution, filtered and dried to give 3-(3-(2-quinolinylmethyloxy)phenoxymethyl)benzoic acid. (M.P. 149°-151° C.)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05059610 |
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| Source dataset | uspto-grants-1991_10 |
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| ORD ID | ord-f5c1bd6f9a7b4b859268b997c8b2d1d8 |
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| Source note | uspto-grants-1991_10 |
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