Sodium cyanoborohydride → HCID 136054883, compound

Participants

Reaction Steps

To a stirred mixture of 136.3 g of 7-(3-fluorophenyl)pyrazolo(1,5-a)pyrimidine-3-carboxamide (prepared as described in Example 11) in one liter of glacial acetic acid at room temperature under nitrogen is added 83.6 g of sodium cyanoborohydride in portions. The mixture is stirred at room temperature for 16 hours. The crystals that form are collected by filtration and triturated with saturated sodium bicarbonate until a pH of 7-8 is achieved. The crystals are then filtered, washed with excess water and dried in vacuo to give 63.0 g of the desired product of the example as cream colored crystals, mp 122°-125° C.

Provenance & Evidence