Thionyl Chloride → 4,5-Dibromothiophene-2-carbonyl chloride

Using the procedure of Preparation A, 2.86 g (10.0 mmoles) of commercially available 4,5-dibromo-2-thiophenecarboxylic acid was added to 10 ml of thionyl chloride to give a heterogeneous mixture. Heating the reaction mixture helped the solution become homogenous. Concentration of the reaction solution gave 3.15 g of crude 4,5-dibromo-2-thiophenecarbonyl chloride as a brown oil. The crude acid chloride, dissolved in 10 ml of N,N-dimethylformamide was slowly added to 1.76 g (8.33 mmoles) of 5-chloro-2,3-dihydro-2-oxo-1H-indole-1-carboxamide and 3.05 g (25.0 mmoles) of 4-(N,N-diemthylamino)pyridine in 40 ml of N,N-dimethylformamide. Workup gave 2.82 g of orange solid which was recrystallized from 2-butanone to give 1.61 g (3.37 mmoles, 40% yield) of pure title compound as a yellow solid, m.p. 229°-231° C.

1. customto give a heterogeneous mixture
2. temperatureHeating the reaction mixture

ORD record

ord-d13cd94f85d64e23ba54254fa3503e7b

Source dataset

uspto-grants-1991_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05059693