Water → HCID 9841326, compound

Participants

Reaction Steps

To a solution of 17.5 g of methyl 2-cyanomethyl benzoate and 16.2 g of phenyl isothiocyanate in 300 ml of tetrahydrofuran was added 4.8 g of a 60% sodium hydride for 20 minutes under an ice-cooling in a stream of nitrogen, and the mixture was stirred for 1 hour at room temperature. To the reaction mixture was added 18.4 g of methyl bromoacetate for 15 minutes, and then the mixture was stirred for 1 hour. To the reaction mixture was added 4.8 g of a 60% sodium hydride, and the mixture was stirred for 14 hours. The reaction mixture was poured into 3 l of water, and the precipitates were collected by a filtration. The precipitates were successively washed with water and acetone, and air-dried, and dried over phosphorus pentaoxide to obtain 25.3 g of the desired product as brown crystals.

Provenance & Evidence