HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropyl iodide → ethyl (RS)-2-[2-(2-methylprop-2-yl)-4-chloropyrimidin-5-yl]-3-methylbutyrate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropyl iodide | HCID 6362 | — |
| Reactant | HCID 817777 | HCID 817777 | — |
| Reactant | Lithium Hexamethyldisilazide | HCID 2733832 | — |
| Product | ethyl (RS)-2-[2-(2-methylprop-2-yl)-4-chloropyrimidin-5-yl]-3-methylbutyrate | HCID 13911486 | — |
Reaction Steps
4-chloro-5-ethoxycarbonylmethyl-2-(2-methylprop-2-yl)pyrimidine was reacted with 2-iodo-propane in the presence of lithium bis(trimethylsilyl)amide according to the procedure illustrated in example 6, to give ethyl (RS)-2-[2-(2-methylprop-2-yl)-4-chloropyrimidin-5-yl]-3-methylbutyrate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04762835 |
| Source dataset | uspto-grants-1988_08 |
| ORD ID | ord-274ef1521d5243b9a88c3ede58a9f262 |
| Source note | uspto-grants-1988_08 |