Phenyl Isothiocyanate → HCID 15027715, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1.81 g of methyl 3-cyanomethylthiophene-2-carboxylate and 1.62 g of phenyl isothiocyanate in 30 ml of tetrahydrofuran was added 480 mg of a 60% sodium hydride with stirring at 0° C. in a stream of nitrogen, and the mixture was stirred for 1 hour at room temperature. To the reaction mixture was added 1.14 ml of methyl bromoacetate at room temperature, and the mixture was stirred for 3 hours. To the reaction mixture was added 480 mg of a 60% sodium hydride, and the mixture was stirred overnight at room temperature. To the reaction mixture was added 100 ml of water, and precipitates were collected by a filtration. The precipitates were successively washed with water, benzene and n-hexane, and dried over to obtain 3.06 g of the desired product as white crystals.

Provenance & Evidence