Water → HCID 15027712, compound

Participants

Reaction Steps

To a solution o 1.05 g of methyl 1-amino-4,5-dihydro-5-oxo-4-phenyl-thieno[2,3-c]isoquinoline-2-carboxylate in 20 ml of dimethylformamide was added 0.55 g of phosphorus oxychloride at room temperature, and the mixture was stirred for 30 minutes. The reaction mixture was poured into water, and neutralized with a saturated sodium bicarbonate aqueous solution, and precipitates were collected by a filtration. The precipitates were washed with water, and dried under reduced pressure. The residue was purified by silica gel column chromatography to obtain 1.09 g of the desired product as pale yellow crystals (eluent: n-hexane/chloroform=1/1).

Provenance & Evidence