反应详情

A mixture of 48.4 g of 3-acetylthiophene and 75 ml of dimethylformamide dimethyl acetal, under nitrogen, is heated for 15 hours on a steam bath. The reaction is concentrated in vacuo and the residue crystallized from methylene chloride/hexane to give 60.55 g (87%) of the desired product, mp 89°-90° C.

1. temperatureunder nitrogen, is heated for 15 hours on a steam bath
2. concentrationThe reaction is concentrated in vacuo
3. customthe residue crystallized from methylene chloride/hexane