1,1,1,3,3-Pentachloropropanone → Pentafluoroacetone
Reaction equation
[F:1][CH:2]([F:11])[CH:3](C(F)F)[C:4]([F:7])([F:6])[F:5].ClC(Cl)(Cl)C(=[O:18])C(Cl)Cl>>[F:5][C:4]([F:7])([F:6])[C:3](=[O:18])[CH:2]([F:11])[F:1]Participants
3
Procedure
As another preparation example, 2-difluoromethyl-1,1,1,3,3-pentafluoropropane may be prepared by fluorinating commercially available 1,1,1,3,3-pentachloro-2-propanone to form 1,1,1,3,3-pentafluoro-2-propanone which may then be reacted with CF2 carbene to form 2-difluoromethyl-1,1,3,3,3-tetrafluoro-1-propene. The 2-difluoromethyl-1,1,3,3,3-tetrafluoro-1-propene may then be hydrogenated to form 2-difluoromethyl-1,1,1,3,3-pentafluoropropane.
Workup
- custommay be prepared
Sources & evidence
- ORD record
- ord-68957f1a258d462f9e2ae4f7f991e304
- Source dataset
- uspto-grants-1991_10
- Patent number
- US05059728
Reaction notes
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