反应详情

26.1 g (258 mmol) of diisopropylamine are added with stirring to a solution of 29.9 g (86 mmol) of the product from Example 17 in 100 ml of toluene. The mixture is heated to reflux and kept at this temperature for 24 hours. After cooling, a solution of 4.1 g of NaOH in 21 ml of water is added. The solid product is filtered off and recrystallized from 25 ml of toluene. A yellowish powder which melts at 179°-184° is obtained.

1. temperatureThe mixture is heated
2. temperatureto reflux
3. temperatureAfter cooling
4. filtrationThe solid product is filtered off
5. customrecrystallized from 25 ml of toluene
6. customA yellowish powder which melts at 179°-184° is obtained