Morpholine → 2-Morpholino-4-(1-hydroxyl-2,2,6,6-tetramethylpiperidine-4-oxy)-6-(2,2,6,6-tetramethylpiperidin-1-yl)-1,3,5-triazine

HRID 345995Notes

Reaction equation

HRID 345995 reaction equation
Cl[C:2]1[N:7]=[C:6]([O:8][CH:9]2[CH2:14][C:13]([CH3:16])([CH3:15])[N:12]([OH:17])[C:11]([CH3:19])([CH3:18])[CH2:10]2)[N:5]=[C:4]([N:20]2[C:25]([CH3:27])([CH3:26])[CH2:24][CH2:23][CH2:22][C:21]2([CH3:29])[CH3:28])[N:3]=1.[NH:30]1[CH2:35][CH2:34][O:33][CH2:32][CH2:31]1>O>[O:33]1[CH2:34][CH2:35][N:30]([C:2]2[N:7]=[C:6]([O:8][CH:9]3[CH2:10][C:11]([CH3:19])([CH3:18])[N:12]([OH:17])[C:13]([CH3:15])([CH3:16])[CH2:14]3)[N:5]=[C:4]([N:20]3[C:21]([CH3:29])([CH3:28])[CH2:22][CH2:23][CH2:24][C:25]3([CH3:27])[CH3:26])[N:3]=2)[CH2:31][CH2:32]1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 199917962-Chloro-4-(1-hydroxyl-2,2,6,6-tetramethylpiperidin-4-oxy)-6-(2,2,6,6-tetramethylpiperidin-1-yl)-1,3,5-triazine2×

Product 1

HCID 199917802-Morpholino-4-(1-hydroxyl-2,2,6,6-tetramethylpiperidine-4-oxy)-6-(2,2,6,6-tetramethylpiperidin-1-yl)-1,3,5-triazine

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

5 g of 2-chloro-4-(1-hydroxyl-2,2,6,6-tetramethylpiperidin-4-oxy)-6-(2,2,6,6-tetramethylpiperidin-1-yl)-1,3,5-triazine (product from Example 36) are stirred under reflux with 50 ml of morpholine for 3 hours. After cooling to 20°, 200 ml of water are added and the precipitate is filtered off. After recrystallization from petroleum ether, the above product is obtained as reddish crystals which melt at 153°-157°.

Workup

  1. temperatureAfter cooling to 20°
  2. filtrationthe precipitate is filtered off
  3. customAfter recrystallization from petroleum ether
  4. customthe above product is obtained as reddish crystals which
  5. custommelt at 153°-157°

Sources & evidence

ORD record
ord-19347bec753a4786b1c09135668d4cbd
Source dataset
uspto-grants-1991_10
Patent number
US05059689

Reaction notes

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