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HRID346022

反应详情

EQUATION

反应方程式

HRID 346022 的结构方程式

REACTANTS

反应物

2
结构：Fc1ccc2nc(CCl)ccc2c1
HCID11241007

2-(chloromethyl)-6-fluoro-quinoline

C10H7ClFN

结构：COc1ccc(O[C@@H]2COc3ccc(O)cc3[C@@H]2O)cc1
HCID67825695

未命名化合物

PRODUCTS

生成物

1
结构：COc1ccc(O[C@@H]2COc3ccc(-c4ccc5cc(F)ccc5n4)cc3[C@@H]2O)cc1
HCID67592265

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

By the method of Example 13, using flash chromatography with 35:1 CH2Cl2 :isopropanol as eluant and recrystallization from CH2Cl2 for purification of the product, the title product of Example 20 (0.20 g, 0.69 mmol) and 6-fluoro-2-chloromethylquinoline were converted to present title product, 0.104 g (34%), m.p. 151°-153.5° C. MS calculated: 447.1486, found: 447.1494.

WORKUP

后处理

  1. customisopropanol as eluant and recrystallization from CH2Cl2
  2. customfor purification of the product