Tetrafluoro-m-phenylenediamine dihydrochloride → HCID 67592279, compound

HRID 346031Notes

Reaction equation

HRID 346031 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][C@H:8]2[C@@H:17]([OH:18])[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([O:19][CH2:20][C:21]4[CH:30]=[CH:29][C:28]5[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=5)[N:22]=4)[CH:15]=3)[O:10][CH2:9]2)[CH:2]=1.C1(N)C(F)=C(F)C(F)=C(N)C=1F.[ClH:43].Cl>>[ClH:43].[ClH:43].[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([CH2:7][C@H:8]2[C@@H:17]([OH:18])[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([O:19][CH2:20][C:21]4[CH:30]=[CH:29][C:28]5[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=5)[N:22]=4)[CH:15]=3)[O:10][CH2:9]2)[CH:2]=1

Participants

3

Reactant 2

HCID 149026Tetrafluoro-m-phenylenediamine dihydrochlorideHCID 14773593HCID 14773593, compound

Product 1

HCID 67592279HCID 67592279, compound

Procedure

By the method of Example 184, cis-3-(3-pyridylmethyl)-6-(2-quinolyl)methoxy-4-chromanol (1.00 g, 2.51 mmol) was converted to 830 mg (70%) of the title dihydrochloride salt, crystallized from a mixture of ethanol, ether and water, m.p. 110° C. (dec.).

Workup

  1. customcrystallized from a mixture of ethanol, ether and water, m.p. 110° C. (dec.)

Sources & evidence

ORD record
ord-e4b8a8722a8a4cca8b4053b5c109d22b
Source dataset
uspto-grants-1991_10
Patent number
US05059609

Reaction notes

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